A REVIEW OF ILOKAASU KäRKKäINEN

The final proposed mechanism of RBC vasodilation during the presence of nitrite is the reduction of nitrite to NO by Hb. Brooks to start with examined the nitrite Hb conversation in 1937 and this work was afterwards extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to type metHb and NO (Brooks, 1937;